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Cocaine is a powerful recreational drug that has a wide range of physical and psychoactive effects including intense feelings of euphoria, happiness, and alertness. Cocaine has gained infamy over the years due to its association with popular culture and celebrity use and abuse. Cocaine continues to be a controversial drug due to its powerful effects on the body, its contentious history, and its addictive nature.
What is Cocaine?
In spite of its recent notoriety, cocaine has a documented history of use by the Amara Indians of Peru. This tribe has “used cocaine” for thousands of years by chewing the leaves of the coca plant .
This low-level usage appears to have produced few adverse effects, presumably due to the low concentration of the active component in the leaves and the laborious act of extracting cocaine by chewing the coca leaves .
However, its use changed after 1859 when the German chemist Albert Niemann purified cocaine .
Around the end of 1884, cocaine started gaining publicity due to the interest conveyed by a number of scientists. Sigmund Freud praised the drug in his famous Cocaine Papers describing its therapeutic properties in relieving depression and anxiety .
Following Freud’s publications, Carl Koller discovered the anesthetic properties of cocaine on the human eye .
Purified cocaine became commercially available when Merck started refining and producing it .
Without regulatory restrictions, cocaine was initially sold as both a therapeutic and consumable product .
However, the passage of the Harrison Narcotics Act of 1914 in the US banned the distribution of cocaine due to widespread cocaine abuse and addiction .
Despite regulatory restrictions, the drug is still sold and used illegally around the world. According to a United Nations report, around 18.3 million people used cocaine in 2014 .
Cocaine is a white crystal powder that can be snorted, smoked, or injected .
Cocaine is called “crack” when is it smoked (freebase form of cocaine). It’s street names include coke, flake, snow, and powder.
How It Works
Cocaine is highly addictive and produces a feeling of euphoria through the brain’s pleasure center (buildup of dopamine in the limbic system) .
Independent of the route of administration (snorted, smoked, or injected), cocaine is rapidly absorbed into the bloodstream and reaches the brain to initiate its psychopharmacological effects [6, 12]. pure crack for sale
Once in the brain, cocaine blocks the reuptake of the neurotransmitters dopamine, noradrenaline, serotonin, and acetylcholine by presynaptic neurons (mesolimbic and mesocortical areas), which increases their effects on the postsynaptic neurons [6, 13, 14].
Also, by blocking neurotransmitter transporters through a similar mechanism, cocaine increases norepinephrine and serotonin, which has a profound effect on both the brain and the heart .
The release of dopamine in the brain causes psychoactive changes as increased body movements and mood .
As shown by animal studies involving cocaine, endothelin-1 plays a major role in narrowing the blood vessels (vasoconstriction) in the brain (cerebrum) . pure crack for sale
Receptor And Transporter Gene Products Affected By Cocaine
Cocaine binds to the following dopamine, serotonin, and norepinephrine transporters and blocks the transport of these neurotransmitters back into the presynaptic terminals enhancing their effects:
- TAAR1 (Trace amine-associated receptor 1) 
- VMAT2 (Vesicular monoamine transporter 2) 
- DBH (Dopamine β-Hydroxylase) 
- DRD2 (Dopamine Receptor D2) 
- SLC6A3 (Dopamine Transporter) 
- SLC6A4 (Serotonin Transporter) 
- SLC6A2 (Norepinephrine Transporter)